B. Lu

The genomic trajectory of ovarian high grade serous carcinoma is determined in STIC lesions

This study shows that high ploidy and whole genome duplication in ovarian high-grade serous carcinoma originate in STIC lesions, indicating early determination of the tumor's genomic trajectory.

Mechanisms mediating arylidene-indolinones induced degradation: thoughts on "Discovery of a Drug-like, Natural Product-Inspired, DCAF11 Ligand Chemotype"

The paper discusses discrepancies in conclusions about arylidene-indolinones' mechanism of action, suggesting possible explanations for conflicting findings on their role as DCAF11 ligands and autophagy-tethering compounds.

DNA Methylome Regulates Virulence and Metabolism in Pseudomonas syringae

This study profiles the DNA methylome of Pseudomonas syringae and shows its role in regulating virulence and metabolism through 6mA methylation.

Architecture of genome-wide transcriptional regulatory network reveals dynamic functions and evolutionary trajectories in Pseudomonas syringae

The paper maps the transcriptional regulatory network of Pseudomonas syringae, identifying hierarchical TF organization and functional roles in virulence and metabolism.

Imaging spectroscopy reveals topographic variability effects on grassland functional traits and drought responses

This study uses high-resolution airborne imaging spectroscopy to analyze functional trait variation and drought responses across topographic gradients in a heterogeneous grassland.

Requirement of GrgA for Chlamydia infectious progeny production, optimal growth, and efficient plasmid maintenance

This paper shows that GrgA is essential for Chlamydia growth, plasmid maintenance, and differentiation, and identifies its role in regulating sigma factors and gene expression.

Assessing generalizability of a dengue classifier across multiple datasets

This study evaluates the generalizability of a dengue classifier across multiple datasets, finding that logistic regression models perform well but require adjustments for new populations.

Renal Cl-/H+ antiporter ClC-5 regulates collagen production and release in Dent Disease models

This study shows that ClC-5 loss-of-function in Dent Disease models increases collagen production and release, contributing to renal fibrosis.

Requirement of GrgA for Chlamydia infectious progeny production

This study identifies GrgA as essential for Chlamydia's secondary differentiation from reticulate bodies to infectious elementary bodies using a novel gene knockdown strategy.

Microbiota-stimulated Interleukin-22 regulates brain neurons and protects against stress-induced anxiety

This study identifies IL-22 as a key immune-to-brain signal that reduces stress-induced anxiety by acting on septal neurons.

Tumor suppressor p53 deficiency increases tumor immunogenicity through promoting IL33-mediated anti-tumor immune responses

This study shows that p53 deficiency in tumors enhances immunogenicity by increasing IL-33, which improves response to PD-1 ICB therapy in a mouse model.

A 4-bp natural deletion of maize Na+/H+ exchanger gene alters maize salt stress tolerance

This paper identifies a 4-bp deletion in the maize ZmSOS1 gene that causes salt sensitivity and develops a molecular marker to improve salt tolerance in breeding programs.

Deterministic evolution and stringent selection during pre-neoplasia

This study models pre-neoplasia in human gastric organoids by inactivating TP53, revealing progression to malignant transcriptional programs and clonal dynamics through experimental evolution.

ZNF598 responds to mitochondrial stress to abort stalled translation on mitochondrial outer membrane and maintain tissue homeostasis

3D Printable High Performance Conducting Polymer Hydrogel for All-Hydrogel Bioelectronics

This paper develops a bi-continuous conducting polymer hydrogel with high electrical conductivity, stretchability, and fracture toughness for 3D printable bioelectronics.

Phylogenomic analyses of Alismatales shed light into adaptations to aquatic environments

This study uses phylogenomic analysis of Alismatales to investigate adaptations to aquatic environments and identify whole-genome duplication events.

An individualized causal framework for learning intercellular communicationnetworks that define microenvironments of individual tumors

The paper develops a causal framework to identify tumor-specific intercellular communication networks in head and neck squamous cell carcinoma, revealing subtype-specific patterns linked to clinical outcomes.

Convergence of MCR-8.2 and chromosome-mediated resistance to colistin and tigecycline in an NDM-5-producing ST656 Klebsiella pneumoniae from a lung transplant patient

This study reports a pan-drug-resistant Klebsiella pneumoniae isolate carrying NDM-5 and MCR-8.2 genes, along with chromosomal resistance mechanisms to colistin and tigecycline.

5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes

This study identifies m5C mRNA modifications mediated by Plasmodium NSUN2 as critical for transcript stability and gametocyte development in malaria parasites.

The SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia

This study identifies the SCP4-STK35/PDIK1L phosphatase-kinase complex as a critical signaling dependency in AML, showing its role in proliferation and amino acid metabolism through dual regulatory mechanisms.

Circulating Clonally Expanded T Cells Reflect Functions of Tumor Infiltrating T Cells

The paper examines circulating T cells sharing TCRs with tumor-infiltrating T cells in metastatic melanoma patients, finding they exhibit effector gene signatures similar to tumor T cells.

Epilepsy-associated Mutations in the Calcium-sensing Receptor Disrupt the Regulation of NALCN Sodium-leak Channel by Extracellular Calcium in Neurons

This study shows that CaSR mutations linked to epilepsy disrupt CaSR's regulation of NALCN sodium-leak channels in neurons, affecting neuronal excitability.

Integrated characterization of SARS-CoV-2 genome, microbiome, antibiotic resistance and host response from single throat swabs

This study uses TRACE-seq to analyze single throat swabs, integrating SARS-CoV-2 genome, microbiome, antibiotic resistance, and host response data.

BacAnt: A Combination Annotation Server for Bacterial DNA Sequences to Identify Antibiotic Resistance Genes, Integrons, and Transposable Elements.

BacAnt is a webserver that simultaneously annotates antibiotic resistance genes, integrons, and transposable elements in bacterial DNA sequences, generating automated genbank files.

Modeling the Degradation Effects of AutophagosomeTethering Compounds (ATTEC)

The paper models the kinetics and steady-state degradation of target proteins by autophagosome tethering compounds (ATTEC), showing how binding affinities affect degradation efficiency.

Negative selection may cause grossly altered but broadly stable karyotypes in metastatic colorectal cancer

This study analyzes longitudinal genomic data from colorectal cancer patients to show that negative selection stabilizes karyotypes during tumor progression and metastasis.

Novel culture method to diagnose fungal infections with biopsy tissues

This paper introduces a novel tissue biopsy culture method that improves fungal detection compared to traditional methods.

Acetylation is required for NLRP3 self-aggregation and full activation of the inflammasome

This study identifies acetylation as essential for NLRP3 inflammasome activation, showing that KAT5-mediated acetylation promotes NLRP3 aggregation and inflammasome assembly.

Membrane metalloendopeptidase suppresses prostate carcinogenesis by attenuating effects of gastrin-releasing peptide on stem/progenitor cells

This study shows MME suppresses prostate cancer by inhibiting GRP/GRPR signaling in stem/progenitor cells, and identifies GRPR as a therapeutic target in MME-low cancers.

Skeletal Muscle mTORC1 Activation Increases Energy Expenditure and Reduces Longevity in Mice

This study shows that activating mTORC1 in skeletal muscle increases energy expenditure but shortens lifespan in mice.