C. Park

Molecular basis for the host range function of the poxvirus PKR inhibitor E3

This paper identifies species-specific interactions between poxvirus PKR inhibitors E3 and K3 and host PKR proteins, challenging the sequestration model for E3 function.

Native Korean wild mice (Mus musculus): molecular phylogeny and morphometrics

The paper analyzes genetic and morphological data of Korean wild mice to determine their phylogenetic relationships and taxonomic status within the Mus musculus subspecies.

Computationally accelerated identification of P-glycoprotein inhibitors

This study identifies nine novel P-gp inhibitors using a computationally accelerated drug discovery pipeline, showing they reverse multidrug resistance in cancer cells with minimal toxicity to non-cancerous cells.

Coordinated Immune Cell Networks in the Bone Marrow Microenvironment Define the Graft versus Leukemia Response with Adoptive Cellular Therapy

The paper analyzes single-cell data from bone marrow samples to identify immune cell interactions that predict response to adoptive cellular therapy in myeloid leukemia.

Regulatory role of cholesterol in modulating actin dynamics and cell adhesive interactions in the trabecular meshwork

This study investigates how cholesterol affects actin dynamics and cell adhesion in trabecular meshwork cells, showing that cholesterol modulates PIP2 levels and integrin distribution, thereby influencing cell stiffness and intraocular pressure.

Plasma cell differentiation, antibody quality, and initial germinal center B cell population depend on glucose influx rate

This study shows that glucose influx is critical for germinal center function and plasma cell production, but plasma cells can also use alternative hexose sugars for antibody secretion.

CDDO-Methyl Ester Inhibits BRAF Inhibitor Resistance and Remodels the Myeloid Compartment in BRAF-mutant Melanoma

This study shows that CDDO-Methyl Ester reduces BRAF inhibitor resistance in melanoma by altering the tumor microenvironment and myeloid cell composition.

SARS-CoV-2 Spike Protein Reduces Burst Activities in Neurons Measured by Micro-Electrode Arrays

This study shows that SARS-CoV-2 S1 protein reduces neuronal burst activity in vitro, while S2 does not, and this effect is blocked by an anti-S1 antibody.

Exogenous TGFβ1 and its mimic HpTGM attenuate the heart's inflammatory response to ischaemic injury and improve long term cardiac outcomes

This study shows that exogenous TGFβ1 and its mimic HpTGM reduce inflammation and infarct size after myocardial infarction, improving cardiac outcomes.

Stricturing Crohn's disease single-cell RNA sequencing reveals fibroblast heterogeneity and intercellular interactions

This study uses single-cell RNA sequencing to analyze fibroblast heterogeneity and interactions in Crohn's disease strictures, identifying CDH11 as a potential therapeutic target.

Murine Alveolar Macrophages Rapidly Accumulate Intranasally Administered SARS-CoV-2 Spike Protein leading to Neutrophil Recruitment and Damage

This study shows that intranasal SARS-CoV-2 Spike protein is rapidly taken up by murine alveolar macrophages, leading to neutrophil recruitment and tissue damage.

Commensal Bacteria Maintain a Qa-1b-restricted Unconventional CD8+ T Population in Gut Epithelium

The paper identifies Qa-1b-restricted CD8+ T cells in the gut epithelium, showing they depend on commensal bacteria for maintenance.

Loss of Linker Histone H1 in the Maternal Genome Influences DEMETER-Mediated Demethylation and Affects the Endosperm DNA Methylation Landscape

This study shows that loss of maternal linker histone H1 in Arabidopsis facilitates DME-mediated demethylation in heterochromatin but has limited effects on endosperm gene transcription and imprinting.

A Long-Circulating Vector for Aptamers Based upon Polyphosphodiester-Backboned Molecular Brushes

This paper develops a long-circulating molecular brush to enhance aptamer stability and bioactivity in vivo.

Adaptive duplication and functional diversification of Protein kinase R contribute to the uniqueness of bat-virus interactions

This study shows that bat PKR genes have evolved through duplication and functional diversification, enabling unique antiviral defenses against DNA and RNA viruses.

Peroxiredoxin 5 regulates osteogenic differentiation via interaction with hnRNPK during bone regeneration

This study identifies Prdx5's role in bone regeneration by regulating osteoblast differentiation through interaction with hnRNPK, impacting osteocalcin expression and osteoclast activity.

G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis

This study identifies GPR151 as a regulator of hepatic gluconeogenesis and links its dysfunction to type 2 diabetes risk.

USP11 promotes endothelial apoptosis-resistance in pulmonary hypertension by deubiquitinating HINT3

This study identifies USP11 as a deubiquitinase that stabilizes HINT3, promoting endothelial apoptosis-resistance in pulmonary hypertension.

PPARγ/ETV2 Axis Regulates Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

This study identifies the PPARγ/ETV2 axis as a novel pathway that suppresses endothelial-to-mesenchymal transition in pulmonary hypertension.

Describing Chemical Kinetics in the Time Dimension with Mean Reaction Time

This paper introduces the concept of mean reaction time as a simpler alternative to rate equations for analyzing complex chemical reactions and demonstrates its application to enzyme kinetics.

Visual Interpretation of the Meaning of kcat/KM in Enzyme Kinetics

The paper visually explains kcat/KM in enzyme kinetics by demonstrating its relationship to reaction energy diagrams and identifying the limiting transition state.

Ribonucleotide Reductase Regulatory Subunit M2 as a Driver of Glioblastoma TMZ-Resistance through Modulation of dNTP Production

This study identifies RRM2 as a driver of TMZ resistance in GBM by modulating dNTP production, showing RRM2 inhibition enhances TMZ efficacy in vivo.

CRISPR-Cas9 Screen Reveals PSMB3 Contributes to Gliomagenesis Through Proteasome-Dependent and Independent Mechanisms

The paper identifies PSMB3 as a contributor to gliomagenesis through proteasome-dependent and independent mechanisms using a CRISPR-Cas9 screen in GBM.

ARF4-mediated Retrograde Trafficking Drives Chemoresistance in Glioblastoma

This study identifies ARF4 as a driver of chemoresistance in glioblastoma through a CRISPR screen and shows it mediates retrograde trafficking of EGFR into the nucleus.

Influenza A M2 Channel Oligomerization is Sensitive to its Chemical Environment

This study shows that influenza A M2 forms various oligomers influenced by chemical environment, challenging the previous monodisperse tetramer model.

De-novo purine biosynthesis is a major driver of chemoresistance in glioblastoma

This study identifies de-novo purine biosynthesis as a driver of chemoresistance in glioblastoma and shows that targeting it with Mycophenolate Mofetil can enhance TMZ efficacy.

The scaffold-dependent function of RIPK1 in dendritic cells promotes injury-induced colitis

This study shows that RIPK1's scaffold function in dendritic cells prevents colonic inflammation and maintains immune homeostasis by inhibiting apoptosis and necroptosis.

Transport Dynamics of MtrD: an RND multidrug efflux pump from Neisseria gonorrhoeae

This study uses molecular dynamics simulations to analyze how MtrD transports Azithromycin and rejects Streptomycin, revealing peristaltic motions and potential multiple transport pathways.

Rapid fall in circulating non-classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury

The paper examines the rapid decrease in non-classical monocytes in STEMI patients post-reperfusion and links it to cardiac injury severity.

Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKR

The paper compares the inhibition of PKR by K3 orthologs from different orthopoxviruses across 17 mammalian species, finding species-specific inhibition and highlighting the need for experimental validation over phylogenetic assumptions.