BiophysicsbioRxiv
Multiple Mechanisms Underlie State-Independent Inhibitory Effects of Norfluoxetine on TREK-2 K2P Channels
P. Proks, M. Schewe, L. J. Conrad…·S. J. Tucker
This study identifies multiple mechanisms by which norfluoxetine inhibits TREK-2 K2P channels, showing state-independent effects and interactions with filter stability and voltage-dependent gating.
DOI 10.1085/jgp.202012812