ImmunologybioRxiv
A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae
P. M. Kaplonek, L. Yao, K. Reppe…·P. H. Seeberger
This paper develops a synthetic glycoconjugate vaccine that combines pneumococcal proteins with a defined oligosaccharide to provide broad protection against multiple serotypes of Streptococcus pneumoniae in animal models.