A. Schaefer

ACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses

The paper identifies ACE2 as a receptor for HKU5 coronaviruses from Pipistrellus abramus bats and investigates receptor tropism across merbecovirus clades.

Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV

This study develops MERS-CoV vaccines using a protein nanoparticle platform, showing they induce strong neutralizing antibodies and protect mice against MERS-CoV challenge.

Proteomic profiling of IDH-wildtype Glioblastoma Tissue and Serum uncovers prognostic Subtypes and Marker Candidates

This study identifies proteomic subtypes and recurrence patterns in IDH-wildtype glioblastoma using tissue and serum samples, revealing prognostic markers and proteomic plasticity in recurrent tumors.

A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines

This paper develops a stabilization strategy for sarbecovirus fusion machinery vaccines, showing broad reactivity and protection against SARS-CoV-2 variants.

Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potential

This study evaluates the antiviral efficacy of GS-5245 against multiple SARS-CoV-2 variants and other coronaviruses, showing broad in vitro activity and protective effects in animal models.

The phenuivirus Toscana virus makes an atypical use of vacuolar acidity to enter host cells

This study identifies Toscana virus as a late-penetrating virus that uses vacuolar acidity for entry, with an optimal fusion pH of 5.5 and infectious particles remaining viable below this threshold.

Engineered Immunogens to Elicit Antibodies Against Conserved Coronavirus Epitopes

This study designs engineered immunogens targeting conserved coronavirus epitopes to elicit broad-spectrum antibodies, showing protection in mice against live virus challenge.

The balance between growth and resistance is shifted to the latter by overaccumulation of chloroplast-nucleus located WHIRLY1 in barley

Overaccumulation of WHIRLY1 in barley shifts the balance from growth to stress resistance by enhancing defense gene expression and reducing photosynthesis and growth.

The common oral parasitic protozoan Entamoeba gingivalis forms cysts in response to antibiotic treatment

This study shows that Entamoeba gingivalis forms cysts in response to antibiotic treatment, which may explain persistent periodontal tissue destruction.

Fc mediated pan-sarbecovirus protection after alphavirus vector vaccination

This study shows that non-neutralizing antibodies targeting FcR4 and spike S2 provide cross-protection against sarbecoviruses after alphavirus vector vaccination.

Changes in calpain-2 expression during glioblastoma progression predisposes tumor cells to temozolomide resistance by minimizing DNA damage and p53-dependent apoptosis

This study shows that calpain-2 expression in glioblastoma cells reduces TMZ-induced DNA damage and p53-dependent apoptosis, leading to chemoresistance.

Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer

The paper uses patient-derived organoids and phosphoproteomics to study signaling crosstalk in colorectal cancer and identify off-target effects of kinase inhibitors.

HLA variants and TCR diversity against SARS-CoV-2 in the pre-COVID-19 era

The paper shows that pre-COVID-19 individuals had genetic TCR repertoire and HLA variants capable of recognizing SARS-CoV-2 infected cells.

A Multitrait Locus Regulates Sarbecovirus Pathogenesis

The paper identifies a multitrait locus on mouse Chromosome 9 that regulates SARS-CoV, SARS-CoV-2, and bat sarbecovirus disease severity, with candidate genes CCR9 and CXCR6.

Stable nebulization and muco-trapping properties of Regdanvimab/IN-006 support its development as a potent, dose-saving inhaled therapy for COVID-19

This paper demonstrates that IN-006, a reformulated Regdanvimab, effectively traps SARS-CoV-2 virus-like particles in human airway mucus and achieves higher lung concentrations in rats when nebulized compared to intravenous delivery.

Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains

This study identifies a biparatopic VH domain that neutralizes SARS-CoV-2 VOCs, including Omicron, with high potency in vitro and in a mouse model.

A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae

This paper develops a synthetic glycoconjugate vaccine that combines pneumococcal proteins with a defined oligosaccharide to provide broad protection against multiple serotypes of Streptococcus pneumoniae in animal models.

Protective efficacy of rhesus adenovirus COVID-19 vaccines against mouse-adapted SARS-CoV-2

This study evaluates the protective efficacy of rhesus adenovirus serotype 52 vaccines against a mouse-adapted SARS-CoV-2 strain, showing robust antibody responses and protection against viral replication and disease.

A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice

A broadly neutralizing antibody protects against multiple SARS-CoV and SARS-CoV-2 variants in mice by targeting a conserved epitope in the receptor-binding domain.

Hexavalent Sperm-Binding IgG Antibody Released from Self-Dissolving Vaginal Film Enables Potent, On-Demand Non-Hormonal Female Contraception

This paper develops a non-hormonal contraceptive method using a hexavalent sperm-binding antibody delivered via a dissolving vaginal film, showing potent sperm inhibition in sheep.

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

This study shows that a SARS-CoV-2 RBD nanoparticle vaccine protects against SARS-CoV-2 and related sarbecoviruses, including variants, in mice and non-human primates.

Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice

This study shows chimeric spike mRNA vaccines protect mice against multiple Sarbecovirus strains, including variants and zoonotic viruses, better than standard SARS-CoV-2 vaccines.

Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice

This study evaluates combination therapies of remdesivir and monoclonal antibodies for SARS-CoV-2 and its B.1.351 variant in mice, showing improved outcomes with the antibody combination.

Antibody potency, effector function and combinations in protection from SARS-CoV-2 infection in vivo

This study evaluates the in vivo protective efficacy of SARS-CoV-2 monoclonal antibodies, finding that in vitro potency does not always predict in vivo activity and that effector function and combinations are critical for protection.

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

This study designs SARS-CoV-2 nanoparticle vaccines that induce strong neutralizing antibodies in mice, with higher titers and lower doses than existing trimer vaccines.

A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine

This paper evaluates an inactivated Newcastle disease virus expressing the SARS-CoV-2 spike protein as a cost-effective vaccine, showing immunogenicity and protective efficacy in animal models.

Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as vaccine candidate

This paper describes NDV vector vaccines expressing SARS-CoV-2 spike protein that protect mice from viral challenge and can be produced cost-effectively in chicken eggs.

A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection

A single intranasal dose of ChAd-SARS-CoV-2-S vaccine prevents SARS-CoV-2 infection and likely confers sterilizing immunity in mice.

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

This study demonstrates that the antiviral NHC/EIDD-2801 inhibits SARS-CoV-2 and multiple coronaviruses, showing therapeutic efficacy and oral bioavailability in mice.