Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel
C. Xiong, K. C. Chua, T. B. Stage, J. Kim, A. Altman-Merino, D. Chan, K. Saraf, A. C. Ferracini, F. Fattahi, D. L. Kroetz
This study uses human iPSC-derived sensory neurons to investigate the neurotoxic effects of paclitaxel and related drugs, finding dose- and time-dependent toxicity with varying IC50 values.
bioRxiv · Jun 4, 2020Pharmacology & Toxicology