Inhibition of muscarinic receptor signaling protects human enteric inhibitory neurons against platin chemotherapy toxicity
M. N. Richter, S. Farahvashi, R. M. Samuel, H. Majd, A. K. Chemel, J. T. Ramirez, A. Majd, M. D. Scantlen, N. Elder, A. Cesiulis, K. Garcia, T. Joshi, M. G. Keefe, B. Samiakalantari, E. M. Turkalj, , F. Fattahi
This study identifies muscarinic receptor signaling as a key driver of platin-induced enteric neuropathy and shows that its inhibition protects neurons from toxicity.
bioRxiv · Mar 8, 2023 · PreprintPharmacology & Toxicology