D. Chan

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes

This study identifies LONP1's role in mitochondrial protein folding and shows its impact on beta cell survival and hyperglycemia in type 2 diabetes.

Mining for disease-associated microbial metabolites in an age-dependent model of multiple sclerosis

The paper identifies a microbial metabolite, indole 3-propionic acid, that can reverse non-remitting EAE in aged mice, suggesting therapeutic potential for progressive MS.

Divergent lineage trajectories and genetic landscapes in human gastric intestinal metaplasia organoids associated with early neoplastic progression

The Hyaluronan Synthase isoforms direct distinct patterns of fibroblast activation linked to fibrosis progression versus resolution following renal ischaemia

This study compares HA and HAS enzyme expression in kidney development, health, disease, and recovery, identifying distinct roles of HAS1 and HAS2 in fibroblast activation linked to fibrosis progression versus resolution.

Development of a robotic cluster for automated and scalable cell therapy manufacturing

This paper develops a robotic system to automate cell therapy manufacturing, demonstrating comparable results to manual methods in expanding human CD8+ T cells.

Pneumatically Controlled Non-Equibiaxial Cell Stretching Device with Live-cell Imaging

This paper develops a pneumatically controlled cell stretcher with live-cell imaging to study mechanical strain effects on cell behavior.

The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral disc

This study shows that BMAL1, a circadian clock factor, regulates ECM homeostasis and cell fate in the intervertebral disc, with its loss causing ECM dysregulation and osteogenic differentiation.

Polyacrylamide-based Hydrogel Coatings Improve Biocompatibility of Implanted Pump Devices

This study develops polyacrylamide-based hydrogel coatings that improve the biocompatibility of implanted medical devices, extending their functional lifetime in animal models.

Kinase Inhibitor Pulldown Assay (KiP) for Clinical Proteomics

The paper introduces a kinase inhibitor pulldown assay (KiP) combined with PRM for clinical proteomics, improving kinase quantification in cancer samples.

Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

This study shows that MFN2 deficiency leads to increased cytosolic Ca2+ and overactivation of RhoA and non-muscle myosin II, causing atypical peripheral actin band formation in mouse embryonic fibroblasts.

Plasma amyloid-β homeostasis is associated with Body Mass Index and weight-loss in people with overweight and obesity

This study examines the relationship between BMI, weight loss, and plasma amyloid-β homeostasis in individuals with overweight and obesity, finding that obesity is linked to lower Aβ42/40 ratios, but weight loss has minimal impact on these markers.

Endogenous production of hyaluronan, PRG4, and cytokines is sensitive to cyclic loading in synoviocytes

This study shows cyclic loading modulates hyaluronan, PRG4, and cytokine production in synoviocytes, with strain magnitude affecting gene expression and cytokine profiles.

Selective BCL-XLAntagonists Eliminate Infected Cells from a Primary Cell Model of HIV Latency but not from Ex Vivo Reservoirs

This study shows BCL-XL antagonists reduce HIV in a cell model of latency but not in ex vivo reservoirs, suggesting resistance in true reservoir cells.

Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel

This study uses human iPSC-derived sensory neurons to investigate the neurotoxic effects of paclitaxel and related drugs, finding dose- and time-dependent toxicity with varying IC50 values.

Combinatorial Polyacrylamide Hydrogels for Preventing Biofouling on Implantable Biosensors

This study develops combinatorial polyacrylamide hydrogels that outperform current anti-biofouling coatings in preventing biofouling on biosensors.

Transcriptome-Wide Combinatorial RNA Structure Probing in Living Cells

This study introduces icLASER, a method to map RNA solvent accessibility transcriptome-wide, and combines it with icSHAPE to predict RNA-protein interactions and polyadenylation sites.

NFATC4 Promotes Quiescence and Chemotherapy Resistance in Ovarian Cancer

This study identifies NFATC4 as a regulator of quiescence and chemotherapy resistance in ovarian cancer, showing its role in promoting a non-proliferative state and poor prognosis.

Microscaled Proteogenomic Methods for Precision Oncology

This study develops microscaled proteogenomic methods for cancer analysis, showing treatment response and resistance mechanisms in ERBB2-positive breast cancers.

Susceptibility to Neutralization by Broadly Neutralizing Antibodies Correlates with Infected Cell Binding for a Panel of Clade B HIV Reactivated from Latent Reservoirs

This study examines the correlation between neutralization breadth and infected-cell binding of broadly neutralizing antibodies against HIV reactivated from latent reservoirs.