Paleolithic Gene Duplications Primed Adaptive Evolution of Human Amylase Locus Upon Agriculture
F. Yilmaz, C. Karageorgiou, K. Kim, P. Pajic, K. Scheer, Human Genome Structural Variation Consortium, C. R. Beck, A.-M. Torregrossa, C. Lee, O. Gokcumen
The paper resolves the amylase locus at nucleotide resolution in modern and ancient humans, showing AMY1 copy number variation predated agriculture and was driven by recombination.
bioRxiv · Nov 27, 2023Evolutionary Biology