Author

K. Stachowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

D. Potter· 2 shared M. Foster· 2 shared A. Norris· 1 shared A. Unnikrishnan· 1 shared C. D. Amero· 1 shared C. S. Thomson· 1 shared D. K. Yadav· 1 shared N. Nassar· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

D. Potter

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Merlin Tumor Suppressor Function is Regulated by PIP2-Mediated Dimerization

R. F. Hennigan, C. S. Thomson, N. Ratner, N. Nassar, K. Stachowski

This study shows Merlin dimerization is regulated by PIP2-mediated conformational changes and phosphorylation, with implications for its tumor suppressor function.

bioRxiv · Nov 11, 2021Cancer Biology

Unloxing the assembly and activation mechanism of Cre recombinase using Cryo-EM

K. Stachowski, A. Norris, D. Potter, V. Wysocki, M. Foster

This paper determines cryo-EM structures of Cre-loxP assembly intermediates to elucidate mechanisms of site selection, strand cleavage order, and activation in the Cre recombinase system.

bioRxiv · Jul 31, 2021Biochemistry

DNA Binding Induces a cis to trans Switch in Cre Recombinase to Enable Intasome Assembly

A. Unnikrishnan, C. D. Amero, D. K. Yadav, K. Stachowski, D. Potter, M. Foster

This paper uses NMR to show that Cre recombinase undergoes a cis-to-trans conformational switch upon DNA binding, enabling intasome assembly and DNA recombination.

bioRxiv · May 24, 2020Biophysics