The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis
O. Alejo-Valle, K. Weigert, R. Bhayadia, M. Ng, S. Emmrich, C. Beyer, K. Schuschel, C. Ihling, A. Sinz, M. Flasinski, H. Issa, E. Regenyi, M. Labuhn, D. Reinhardt, M.-L. Yaspo, , J.-H. Klusmann
This paper identifies ARID3A repression by miR-125b as a key driver of megakaryoblastic leukemia, showing that restoring ARID3A expression can reverse differentiation arrest in AMKL.
bioRxiv · Apr 26, 2021Cancer Biology