M. Ng

Characterization of a novel mouse model for Fuchs Endothelial Corneal Dystrophy

This paper develops a mouse model that recapitulates all major features of Fuchs Endothelial Corneal Dystrophy (FECD) through combined genetic and dietary manipulations.

The Septin Cytoskeleton is Required for Plasma Membrane Repair

This study identifies SEPT7 as a critical component of the septin cytoskeleton required for plasma membrane repair, showing its role in forming repair domains with F-actin and ANXA2.

Exomap1 mouse: a transgenic model for in vivo studies of exosome biology

The exomap1 mouse model expresses HsCD81mNG to study exosome biology in vivo, showing cell type-specific exosome contributions and confirming CD81 as an exosome-specific marker.

Allelic variation in Class I HLA determines pre-existing memory responses to SARS-CoV-2 that shape the CD8+ T cell repertoire upon viral exposure

The paper characterizes CD8+ T cell responses to SARS-CoV-2 across HLA alleles, showing HLA genotype influences pre-existing immunity and immune repertoire upon viral exposure.

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis

This paper identifies ARID3A repression by miR-125b as a key driver of megakaryoblastic leukemia, showing that restoring ARID3A expression can reverse differentiation arrest in AMKL.

An SNP variant MT1-MMP with a defect in its collagenolytic activity confers the fibrotic phenotype of Dupuytren's Disease

This study identifies an SNP variant in MMP14 that reduces collagenolytic activity, contributing to the fibrotic phenotype of Dupuytren's Disease.

Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence

The paper models viral dynamics in bat cell lines with constitutive immune responses, finding that robust antiviral defenses correlate with higher viral propagation rates and suggest implications for zoonotic emergence.

Phenotypic plasticity as a mechanism of cave colonization and adaptation

This study shows that cave-related traits in Astyanax mexicanus can appear within one generation through phenotypic plasticity, not just genetic adaptation.