BiochemistrybioRxiv
Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors
J. Felix, K. Weinhaupl, C. Chipot…·H. Fraga
The paper investigates how bortezomib activates ClpP protease by mimicking a substrate and inducing allosteric conformational changes that enhance its interaction with ClpX.
DOI 10.1126/sciadv.aaw3818