Cell BiologybioRxivPreprint
Aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk
P. R. Goody, D. Christmann, D. Goody…·M. R. Hosen
This study identifies miR-145-5p as a key regulator of aortic valve calcification through EV-mediated crosstalk, showing it suppresses ZEB2 to enhance ALPL expression and promote calcification in valvular interstitial cells.