Author

Kai Xu

Boston Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adam Yongxin YeiD· 1 shared Aditi Mhatre· 1 shared Barton L. WicksteediD· 1 shared Brian Thomas LaydeniD· 1 shared Chioma NnyamahiD· 1 shared David G. SchatziD· 1 shared Frederick W. AltiD· 1 shared Jack A. GilbertiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Adam Yongxin YeORCID

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2 papers

Recent·Most cited

Human antibody heavy chain variable region exon interacts with 3' regulatory region to form a stable somatic hypermutation center

Ying Guan, Mariia Mikhova, Zhuo Yang, Kai Xu, Shuxian Xie, Xin Lin, Adam Yongxin Ye, Taimor Williams, Jianshu Wang, David G. Schatz, Frederick W. Alt, Xi Chen

The paper demonstrates that a human antibody heavy chain variable region exon forms a stable somatic hypermutation center (SHM-C) through interaction with 3' regulatory regions, supporting AID access and SHM in non-dividing cells.

Proceedings of the National Academy of Sciences · Sep 28, 2026Peer-reviewedImmunology

A high fermentable fiber Western diet reduces indole levels

Medha Priyadarshini, Julianne A. Jorgensen, Sophia R. Chang Stauffer, Lina Issa, Nupur Pandya, Chioma Nnyamah, Kai Xu, James Boyett, Parneet Kular, Aditi Mhatre, Vishal H Brahambhatt, Jack A. Gilbert, Md Wasim Khan, Barton L. Wicksteed, Yang David Dai, Brian Thomas Layden

This study shows that adding fermentable fiber to a Western diet reduces indole levels and improves gut microbiota diversity and metabolic health in mice.

bioRxiv · Jan 30, 2026 · PreprintPhysiology