Robust V(D)J Recombination in the Absence of SA1/2-mediated Chromatin Loops
Zhuo Yang, Yu Fu, Mariia Mikhova, David Chen, Camille Hebert, Adam Yongxin Ye, Xin Lin, Taimor Williams, Hongli Hu, Zhaoqing Ba, Job Dekker, Fred W. Alt
This study shows that SA1/2 are not essential for V(D)J recombination in G0/G1-arrested cells, but their absence disrupts chromatin loops and long-range Igh recombination, while Ig{kappa} recombination remains functional.
bioRxiv · Oct 11, 2026 · PreprintImmunology