Adam Yongxin Ye

This study shows that SA1/2 are not essential for V(D)J recombination in G0/G1-arrested cells, but their absence disrupts chromatin loops and long-range Igh recombination, while Ig{kappa} recombination remains functional.

The paper demonstrates that a human antibody heavy chain variable region exon forms a stable somatic hypermutation center (SHM-C) through interaction with 3' regulatory regions, supporting AID access and SHM in non-dividing cells.

This paper develops six mouse models with engineered antibody repertoires to study and optimize strategies for inducing HIV-1 broadly neutralizing antibodies.

TrieDedup is a trie-based deduplication algorithm that efficiently handles ambiguous bases in high-throughput sequencing by reducing memory usage and increasing speed compared to pairwise comparison methods.

The paper shows that Gb3 lipid on GC B cells enhances antibody affinity and breadth, promoting cross-protective immunity against influenza.

Scratch-AID automatically detects and quantifies mouse scratching behavior with high accuracy, outperforming manual methods in various itch models and drug screening applications.

The paper shows that Ku70 suppresses alternative end-joining (A-EJ) in G1-arrested progenitor B cells, directing DSB repair toward classical nonhomologous end-joining (C-NHEJ) and preventing translocations.

MosaicBase is a database of postzygotic mosaic variants in noncancer diseases and asymptomatic individuals, revealing distinct genomic features of disease-causing variants.

The paper profiles somatic L1Hs insertions in Rett patients and healthy controls, finding increased insertions in the brain and altered genomic patterns linked to MECP2 dysfunction.

The paper identifies and characterizes two types of postzygotic single-nucleotide mosaicisms in healthy individuals using whole-genome sequencing across multiple organs.