ImmunologybioRxivPreprint
Chronic Infection Perturbs the Affinity Hierarchy of Antiviral B Cells
Mirela Dimitrova, Tiago Abreu-Mota, Jonas Fixemer…·Daniel D. Pinschewer
This study shows that chronic viral infection disrupts B cell affinity hierarchies by preferentially causing attrition of high-affinity B cells due to excessive antigen stimulation.