mTORC1-dependent control of Hedgehog signaling mediates nutrient-responsive licensing of intestinal stem cell differentiation
Gaia Fabris, Simon Biaudet, Atte Hallasaari, Tuuli Kirkinen, Kari Moisio, Krista Kokki, Simon Andersson, Pekka Katajisto, Ville Hietakangas
This study identifies an mTORC1-PWP1-Hedgehog circuit that links nutrient metabolism to intestinal stem cell differentiation in Drosophila, showing its role in aging and tissue renewal.
bioRxiv · Nov 4, 2026 · PreprintPhysiology