BiochemistrybioRxivPreprint
Tryptanthrin Analogs Substoichiometrically Inhibit Seeded and Unseeded Tau4RD Aggregation
Ellie I. James, David W. Baggett, Edcon Chang…·Abhinav Nath
The paper identifies tryptanthrin analogs as potent substoichiometric inhibitors of tau4RD aggregation, showing low nanomolar potency and demonstrating structure-activity relationship principles for tau targeting.
DOI 10.1101/2024.02.02.578649