This study identifies genetic variants associated with parental longevity using GWAS on 75,000 UK Biobank participants, finding multiple protective factors linked to longer lifespan.

DOI 10.18632/aging.100930

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𝕏 PostBluesky

GeneticsDiabetologiaPeer-reviewedMar 10, 2016

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes respectively

Andrew R Wood, Jessica Tyrell, Robin Beaumont…·Michael N Weedon

The paper identifies recessive genetic effects at FTO and CDKAL1 loci for obesity and type 2 diabetes using dominance deviation models in large cohorts.

DOI 10.1007/s00125-016-3908-5

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𝕏 PostBluesky

GeneticsbioRxivOct 19, 2015

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause, and impact reproductive health: a UK Biobank study

Katherine S Ruth, Robin N Beaumont, Jessica Tyrrell…·Anna Murray

This study identifies a genetic variant lowering FSH levels that is associated with longer menstrual cycles, later menopause, and reduced endometriosis risk, but not with PCOS or male infertility.

DOI 10.1093/humrep/dev318

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𝕏 PostBluesky

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Genome-wide association analyses in &gt;119,000 individuals identifies thirteen morningness and two sleep duration loci

HUMAN LONGEVITY IS INFLUENCED BY MANY GENETIC VARIANTS: EVIDENCE FROM 75,000 UK BIOBANK PARTICIPANTS

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes respectively

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause, and impact reproductive health: a UK Biobank study

Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci