Cell BiologyScientific ReportsPeer-reviewed
Evolution of cullin E3 ubiquitin ligases and function in trypanosomes
Ricardo Canavate Del Pino, Martin Zoltner, Kayo Yamada, Mark C. Field
The paper reconstructs the evolution of cullin-RING E3 ubiquitin ligases across eukaryotes and experimentally characterizes two cullin complexes in trypanosomatids, revealing lineage-specific diversity and novel substrate specificity.