ImmunologybioRxivPreprint
STING recruits NLRP3 to the ER and deubiquitinates NLRP3 to activate the inflammasome
Wenbiao Wang, Dingwen Hu, Yuqian Feng…·Jianguo Wu
This study shows STING activates the NLRP3 inflammasome by recruiting NLRP3 to the ER and deubiquitinating it, enhancing IL-1β secretion and inflammatory responses.