A stress-NRF2 response axis polarises tumor macrophages and undermines immunotherapy
Dominik J. Schaer, Nadja Schulthess-Lutz, Livio Baselgia…·Florence Vallelian
This study identifies NRF2 as a stress-response axis that polarizes tumor macrophages into immunosuppressive, therapy-resistant states, and shows that inhibiting NRF2 can restore immunotherapy efficacy.