Kevin D. Costa

This study shows GBM cells use Plexin-B2 to regulate membrane tension and mechano-electrical coupling for migration through confined spaces.

This study generates cardiac resident-like macrophages and cardiomyocytes from iPSCs to investigate their interactions in 2D and 3D settings, showing improved cardiomyocyte maturation and function when co-cultured.

This paper develops human mini-heart models of HFpEF, identifies SERCA2a downregulation, and demonstrates gene therapy efficacy, leading to a first-in-human clinical trial.