Kevin D. Costa

This study shows GBM cells use Plexin-B2 to regulate membrane tension and mechano-electrical coupling for migration through confined spaces.

This study generates cardiac resident-like macrophages and cardiomyocytes from iPSCs to investigate their interactions in 2D and 3D settings, showing improved cardiomyocyte maturation and function when co-cultured.

This paper develops human mini-heart models of HFpEF, identifies SERCA2a downregulation, and demonstrates gene therapy efficacy, leading to a first-in-human clinical trial.

This study uses finite element modeling to evaluate auxetic patch materials for acute myocardial infarction repair, finding that heterogeneous designs can restore LV function without adverse effects.

This study investigates how intrinsic mechanobiological properties of aortic smooth muscle cells from Marfan Syndrome patients contribute to aneurysm localization in the ascending aorta.

The paper develops a robotic system for precise cell seeding in microfluidic chips to improve the repeatability and physiological relevance of tube-shaped organoids.

The paper describes the development of a custom robotic system for automated data collection and stimulation of microfluidic organoid chips.