Molecular BiologybioRxivPreprint
TRMT10A deficiency and tRNA fragmentation disrupt human pancreatic β-cell identity and insulin maturation
Cristina Moreno‐Castro, María Nicol Arroyo, Khadija Benabdallah…·Mariana Igoillo‐Esteve
This study shows TRMT10A deficiency causes β-cell dysfunction by promoting tRNA fragmentation and disrupting PCSK1 expression, leading to impaired insulin maturation and glucose-stimulated insulin secretion.
DOI 10.64898/2026.07.22.739528