NeurosciencebioRxivPreprint
Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus
Leslie Hassanein, Bernard Mulvey, Harris E. Blankenship…·Alexa F. Iannitelli
This study shows that tyrosinase-induced neuromelanin accumulation in mouse locus coeruleus neurons causes hyperactivity, transcriptional changes, and degeneration, mimicking early stages of Alzheimer's and Parkinson's disease.
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