BioinformaticsbioRxivPreprint
✦ In-depth digest
Inferring disruption of directed graphs using LIKA reveals altered protein phosphorylation networks in schizophrenia
Lujing Zhang, Andrew G. DeMarco, Kimia Ghafari…·Kathryn Roeder
LIKA, a likelihood model over many-to-many kinase-substrate networks, beats KSEA in simulations with shared substrates, recovers EGFR and ABL1 in cell lines, and ranks MAPK3 first in schizophrenia cortex.
DOI 10.64898/2026.08.06.743374