BiochemistryNature CommunicationsPeer-reviewed
Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP
Cory M. Nadel, Saugat Pokhrel, Kristin Wucherer…·Jason E. Gestwicki
This study identifies phosphorylation at residue S416 on tauC3 as a mechanism that inhibits its degradation by CHIP, contributing to its accumulation in Alzheimer's disease.
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