PathologybioRxivPreprint
Astrocytic Cathepsin D truncates α-synuclein and promotes Lewy neurite-like aggregation in neurons
Hiroshi Hanafusa, Kota Ohashi, Hiromu Shojima…·Kunihiro Matsumoto
This study shows astrocytes process and propagate α-synuclein aggregates via lysosomal protease Cathepsin D, promoting Lewy neurite-like aggregation in neurons.
DOI 10.1101/2025.10.03.680233