Cis-Regulatory Evolution of CCNB1IP1 Driving Gradual Increase of Cortical Size and Folding in primates
Ting Hu, Pengcheng Ma, Yifan Kong, Yulian Tan, Xuelian Sun, Jianhong Wang, Kun Xiang, Bingyu Mao, Qingfeng Wu, Soojin V. Yi, Lei Shi
This study identifies CCNB1IP1 as a regulator of neocortex size and folding in primates, showing its expression increased alongside brain evolution.
Nature Genetics · Sep 29, 2026Peer-reviewedEvolutionary Biology