BiophysicsbioRxivPreprint
A novel AR molecular glue degrader via bivalent engagement of the N-terminal domain and RNF213-UBE2J2 complex
Kunzhong Wu, Qiong Wu, Yongzhi Lu…·Jinsai Shang
This paper introduces GZL626, a novel AR degrader that targets the N-terminal domain and RNF213-UBE2J2 complex, effectively degrading AR and AR-V7 and showing antitumor and antiviral activity.
DOI 10.64898/2026.07.14.738453