BiochemistrybioRxivPreprint
Next-generation genetically encoded biosensors for spatiotemporal intracellular pH monitoring, mapping, and profiling
Sam Taylor, Bruno Colon, Kyutae D Lee…·Daniel G. Isom
This paper develops ORION, a genetically encoded BRET pH sensor with improved performance and broader pH range, and demonstrates its use in identifying acid imprinting states in cancer cells.
DOI 10.64898/2026.05.19.726343