Cancer BiologybioRxiv
Negative trade-off between neoantigen repertoire breadth and the specificity of HLA-I molecules shapes antitumour immunity
M. Manczinger, G. Balogh, B. T. Papp…·C. Pal
The paper finds that HLA-I alleles with high peptide binding promiscuity are associated with worse prognosis in cancer patients treated with immune checkpoint inhibitors.
DOI 10.1038/s43018-021-00226-4