B. Papp

SARS CoV-2 Envelope protein alters calcium signaling via SERCA interactions

This study shows that SARS-CoV-2 E protein interacts with SERCA2b and regulins, altering calcium homeostasis and potentially contributing to viral pathogenesis.

Pathogen genomic surveillance as a scalable framework for precision phage therapy

This paper develops a scalable framework for precision phage therapy by combining genomic surveillance and phage typing to target carbapenem-resistant Acinetobacter baumannii.

Chloroplastic ascorbate acts as a regulatory hub in plant metabolism regardless of oxidative stress

This study shows chloroplastic ascorbate modulates plant metabolism through global metabolome rewiring and enzyme interactions, independent of oxidative stress.

The calcium pump PMCA4b promotes epithelial cell polarization and lumen formation

This study shows PMCA4b promotes epithelial cell polarization and lumen formation, with implications for cancer progression.

Antibiotics of the future are prone to resistance in Gram-negative pathogens

This study shows new antibiotics are as likely to face resistance as existing ones in Gram-negative bacteria, highlighting the need for narrow-spectrum therapies.

Metabolic complexity increases adaptability

This study shows that metabolic complexity enhances adaptability in bacteria, as generalist E. coli strains require fewer new reactions to adapt than specialized endosymbionts.

Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan

The paper shows that metabolite exchange between cells extends lifespan in yeast by creating a pro-survival metabolic environment.

Negative trade-off between neoantigen repertoire breadth and the specificity of HLA-I molecules shapes antitumour immunity

The paper finds that HLA-I alleles with high peptide binding promiscuity are associated with worse prognosis in cancer patients treated with immune checkpoint inhibitors.

Unmatched level of molecular convergence among deeply divergent complex multicellular fungi

The paper shows that genes for complex multicellularity have converged across distant fungal clades, indicating genomic constraints on evolutionary paths.

Chemical-genetic profiling reveals cross-resistance and collateral sensitivity between antimicrobial peptides

This study uses a chemical-genetic approach to analyze resistance determinants of E. coli to 15 AMPs, revealing cross-resistance and collateral sensitivity patterns.

Phylogenetic barriers to horizontal transfer of antimicrobial peptide resistance genes in the human gut microbiota

This study investigates the horizontal transfer of antimicrobial peptide resistance genes in the human gut microbiota, finding that their transfer rates and functional compatibility are lower than antibiotic resistance genes.

Pathogen diversity drives the evolution of promiscuous peptide binding of human MHC-II alleles

This study shows that pathogen diversity drives the evolution of promiscuous peptide binding in human MHC-II alleles, explaining their global distribution and immune function.