Interferons Reshape the 3D Conformation and Accessibility of Macrophage Chromatin
E. Platanitis, S. Güner, A. R. S. J. Geetha, L. Boccuni, A. Vogt, M. Novatchkova, A. Sommer, M. Müller, T. Decker
This study shows that type I and type II interferons induce similar epigenomic and transcriptional changes in macrophages, including 3D chromatin rearrangements and increased DNA accessibility at ISG loci.
bioRxiv · Mar 9, 2021Immunology