Author

T. Decker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 3 Approach:statistical model· 3

Frequent Co-Authors

E. Platanitis· 3 shared A. Vogt· 2 shared K. Fischer· 2 shared M. Novatchkova· 2 shared A. Arnett· 1 shared A. Bosch· 1 shared A. Cantoran-Garcia· 1 shared A. Eichhorn· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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3 shared papersImmunology

E. Platanitis

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Terpenoid balance in Aspergillus nidulans unveiled by heterologous squalene synthase expression

S. C. Park, B. N. Steffan, F. Y. Lim, R. Gupta, F. A. Butun, H. Chen, R. Ye, T. Decker, C. C. Wu, N. L. Kelleher, J. W. Bok, N. P. Keller

The paper shows that expressing a heterologous squalene synthase from Pseudogymnoascus destructans in Aspergillus nidulans alters terpene biosynthesis, increasing squalene and new nidulenes while reducing austinol.

bioRxiv · Oct 20, 2023 · PreprintMicrobiology

Dynamic control of gene expression by ISGF3 and IRF1 duringIFNbeta and IFNgamma signaling

A. Ravi Sundar Jose Geetha, K. Fischer, G. Smesnik, A. Vogt, E. Platanitis, M. Muller, M. Farlik, T. Decker

The paper shows that IFN-I and IFN-gamma produce distinct transcriptomes over time due to different roles of ISGF3 and IRF1 in enhancer activation and chromatin accessibility.

bioRxiv · Jun 28, 2023Immunology

Vgamma9+Vdelta2+Tcell-mediated purging of Listeria monocytogenes-infected epithelial cells requires butyrophilin 3A genes

K. Fischer, M. Bradlerova, T. Decker, V. Supper

The paper shows that Vgamma9+Vdelta2+ T cells purge Listeria monocytogenes-infected epithelial cells via BTN3A1 and BTN3A3, with BTN3A3 possibly presenting different antigens.

bioRxiv · Jun 7, 2023 · PreprintImmunology

SPOP targets the immune transcription factor IRF1 for proteasomal degradation

M. Vunjak, I. Schwartz, A. Cantoran-Garcia, M. Mastrovito, M. Hinterndorfer, M. de Almeida, V. Budroni, J. Wang, K. Froussios, J. Jude, T. Decker, J. Zuber, G. A. Versteeg

This study identifies SPOP as an E3 ligase that targets IRF1 for proteasomal degradation, highlighting its role in regulating IRF1 levels to balance immune response and tumor suppression.

bioRxiv · Oct 10, 2022Cell Biology

Genomes of novel Myxococcota reveal severely curtailed machineries for predation and cellular differentiation

C. Murphy, C. Cavalliere, J. Cornell, J. Higgs, S. Mares, C. Meili, V. Andreev, N. Bircher, T. Decker, R. Dohmen, A. Eichhorn, A. Grinnell, C. Jett, R. Khadka, J. Liu, , N. H. Youssef

This study analyzes genomes of novel Myxococcota from anaerobic habitats, revealing reduced capacities for predation and cellular differentiation compared to soil-dwelling relatives.

bioRxiv · Jul 6, 2021Microbiology

Interferons Reshape the 3D Conformation and Accessibility of Macrophage Chromatin

E. Platanitis, S. Güner, A. R. S. J. Geetha, L. Boccuni, A. Vogt, M. Novatchkova, A. Sommer, M. Müller, T. Decker

This study shows that type I and type II interferons induce similar epigenomic and transcriptional changes in macrophages, including 3D chromatin rearrangements and increased DNA accessibility at ISG loci.

bioRxiv · Mar 9, 2021Immunology

The CDK8 inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4+ T cells via a novel CDK8-GATA3-FOXP3 pathway

A. Arnett, K. G. Moo, K. J. Flynn, T. B. Sundberg, L. Johannessen, A. F. Shamji, N. S. Gray, T. Decker, V. H. Gersuk, D. E. Levy, I. J. Marie, Z. S. Rahman, Y. Zheng, P. S. Linsley, R. J. Xavier, B. Khor

The paper identifies DCA as a CDK8 inhibitor that induces a tolerogenic immunophenotype in CD4+ T cells through a novel CDK8-GATA3-FOXP3 pathway, promoting Treg and Th2 differentiation while inhibiting Th1 and Th17.

bioRxiv · Mar 4, 2021 · PreprintImmunology

Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs

R. Murugan, S. W. Scally, G. Costa, G. Mustafa, E. Thai, T. Decker, A. Bosch, K. Prieto, E. A. Levashina, J.-P. Julien, H. Wardemann

The paper characterizes 200 human monoclonal PfCSP antibodies, showing that high affinity to a conserved NANP motif, not cross-reactivity, correlates with parasite inhibition and protection.

bioRxiv · Oct 9, 2019Immunology

Homeostatic and Interferon-induced gene expression represent different states of promoter-associated transcription factor ISGF3

E. Platanitis, D. Demiroz, C. Capelle, A. Schneller, M. Hartl, T. Gossenreiter, M. Mueller, M. Novatchkova, T. Decker

The paper shows that interferons switch macrophages from resting to gene expression by altering ISGF3 subunit composition, with IFNγ inducing full ISGF3 complex formation on DNA.

bioRxiv · Jul 25, 2018 · PreprintImmunology