Author

E. Platanitis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:transcription & RNA processing· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

T. Decker· 3 shared A. Vogt· 2 shared M. Novatchkova· 2 shared A. R. S. J. Geetha· 1 shared A. Ravi Sundar Jose Geetha· 1 shared A. Schneller· 1 shared A. Sommer· 1 shared C. Capelle· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

T. Decker

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3 papers

Recent·Most cited

Dynamic control of gene expression by ISGF3 and IRF1 duringIFNbeta and IFNgamma signaling

A. Ravi Sundar Jose Geetha, K. Fischer, G. Smesnik, A. Vogt, E. Platanitis, M. Muller, M. Farlik, T. Decker

The paper shows that IFN-I and IFN-gamma produce distinct transcriptomes over time due to different roles of ISGF3 and IRF1 in enhancer activation and chromatin accessibility.

bioRxiv · Jun 28, 2023Immunology

Interferons Reshape the 3D Conformation and Accessibility of Macrophage Chromatin

E. Platanitis, S. Güner, A. R. S. J. Geetha, L. Boccuni, A. Vogt, M. Novatchkova, A. Sommer, M. Müller, T. Decker

This study shows that type I and type II interferons induce similar epigenomic and transcriptional changes in macrophages, including 3D chromatin rearrangements and increased DNA accessibility at ISG loci.

bioRxiv · Mar 9, 2021Immunology

Homeostatic and Interferon-induced gene expression represent different states of promoter-associated transcription factor ISGF3

E. Platanitis, D. Demiroz, C. Capelle, A. Schneller, M. Hartl, T. Gossenreiter, M. Mueller, M. Novatchkova, T. Decker

The paper shows that interferons switch macrophages from resting to gene expression by altering ISGF3 subunit composition, with IFNγ inducing full ISGF3 complex formation on DNA.

bioRxiv · Jul 25, 2018 · PreprintImmunology