BiophysicsbioRxiv
A computational study to assess the pathogenicity of single or combinations of missense variants on respiratory Complex I
L. Rigobello, F. Lugli, L. Caporali…·F. Musiani
This study uses molecular dynamics simulations to assess how single or combined missense variants in respiratory complex I affect its function, finding that some variants stiffen key regions and worsen dysfunction.
DOI 10.1016/j.ijbiomac.2024.133086