ImmunologybioRxiv
SARS-CoV-2 spike protein arrested in the closed state induces potent neutralizing responses
G. W. Carnell, K. A. Ciazynska, D. A. Wells…·J. A. G. Briggs
This study evaluates closed-state SARS-CoV-2 spike protein immunization in mice, finding it induces potent neutralizing antibodies and T-cell responses, with unique binding properties compared to standard S protein constructs.
DOI 10.1128/jvi.00203-21