Author

L. D. Hurst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. T. Ho· 2 shared A. Castillo Morales· 1 shared A. H. van Vliet· 1 shared A. J. Taylor· 1 shared A. M. Rice· 1 shared B. Pascoe· 1 shared B. Young· 1 shared C. M. Kobras· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersEvolutionary Biology

A. T. Ho

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Author profile →

3 papers

Recent·Most cited

Sequence conservation need not imply purifying selection: evidence from mammalian stop codon usage

A. T. Ho, L. D. Hurst

The paper shows that sequence conservation in mammalian stop codons can result from GC-biased gene conversion rather than purifying selection.

bioRxiv · Mar 2, 2022 · PreprintEvolutionary Biology

A two-hit epistasis model prevents core genome disharmony in recombining bacteria

A. J. Taylor, K. Yahara, B. Pascoe, L. Mageiros, E. Mourkas, J. K. Calland, S. Puranen, M. D. Hitchings, K. A. Jolley, C. M. Kobras, S. C. Bayliss, N. J. Williams, A. H. van Vliet, J. Parkhill, M. C. Maiden, , S. K. Sheppard

The paper shows that recombination in bacteria can overcome genomic disharmony through a two-hit epistasis model, allowing beneficial gene combinations to be reinstated in new genetic backgrounds.

bioRxiv · Mar 15, 2021 · PreprintMicrobiology

Evidence for strong mutation bias towards, and selection against, T/U content in SARS-CoV2: implications for attenuated vaccine design.

A. M. Rice, A. Castillo Morales, A. T. Ho, C. Mordstein, S. Mühlhausen, S. Watson, L. Cano, B. Young, G. Kudla, L. D. Hurst

The paper analyzes SARS-CoV-2 mutation patterns to show strong T/U mutation bias and selection against T, suggesting a strategy for vaccine attenuation by increasing usage of common synonymous codons.

bioRxiv · May 11, 2020 · PreprintEvolutionary Biology