S. Watson

Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencing

The paper characterizes the immune repertoire of a humanised transgenic mouse using immunophenotyping and high-throughput sequencing, showing similarities to human BCR repertoires.

Novel strains of Campylobacter cause diarrheal outbreak in Rhesus macaques (Macaca mulatta) of Kathmandu Valley

This study identifies Campylobacter spp. as a cause of a 2018 diarrhea outbreak in Rhesus macaques in Kathmandu Valley, detecting novel strains and linking them to human and animal infections.

Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammation

The paper identifies a copper-signaling pathway involving CD44 and mitochondrial copper(II) that drives inflammation and cell plasticity, and shows a metformin-based drug reduces inflammation in infection models.

A Novel 3D Co-culture Platform for Integrating Tissue Interfaces for Tumor Growth, Migration and Therapeutic Sensitivity: PP-3D-S

This paper develops a 3D co-culture platform (PP-3D-S) to model tumor growth, migration, and therapeutic response in a more physiological setting than traditional in vitro systems.

VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis

This study identifies VGLL2-NCOA2 as an oncogene driving pediatric sarcomagenesis by reactivating developmental programs, with ARF6 overexpression as a potential therapeutic target.

Crosstalk between chloroplast protein import and the SUMO system revealed through genetic and molecular investigation

The paper shows that the SUMO system regulates TOC complex stability and chloroplast development in Arabidopsis by stabilizing TOC proteins.

Evidence for strong mutation bias towards, and selection against, T/U content in SARS-CoV2: implications for attenuated vaccine design.

The paper analyzes SARS-CoV-2 mutation patterns to show strong T/U mutation bias and selection against T, suggesting a strategy for vaccine attenuation by increasing usage of common synonymous codons.

CIC-DUX4 expression drives the development of small round cell sarcoma in transgenic zebrafish: a new model revealing a role for ETV4 in CIC-mediated sarcomagenesis

This study establishes a zebrafish model of CIC-DUX4 sarcoma, showing that CIC-DUX4 drives tumor development and that Etv4 is critical for its oncogenic effects.