B. Pascoe

Genomic tailoring of autogenous poultry vaccines to reduce Campylobacter from farm to fork

This paper develops a genomic autogenous vaccine for poultry to reduce Campylobacter, showing reduced extra-intestinal survival genes and meat surface survival in vaccinated flocks.

Investigation of swine caecal microbiomes in the northern region of Thailand

This study investigates swine caecal microbiomes in northern Thailand, identifying commensal and pathogenic bacteria, antimicrobial resistance genes, and their implications for food safety and public health.

Contrasting genes conferring short and long-term biofilm adaptation in Listeria

This study identifies 273 genes associated with biofilm formation in Listeria monocytogenes through GWAS and 220 genes through RNAseq, finding fewer overlaps than expected, suggesting distinct evolutionary adaptation mechanisms.

Colistin resistance and resistance determinants are mobile among Salmonella enterica isolates from diseased and healthy pigs in Thailand

The paper examines colistin resistance and resistance determinants in Salmonella isolates from Thai pigs, finding widespread multidrug resistance and the presence of the mcr-1 gene in both healthy and diseased pigs.

Assessing the pathogenic potential of less common Salmonella enterica serotypes circulating in the Thai pork production chain

The paper assesses the pathogenic potential of less common Salmonella enterica serotypes from the Thai pork production chain, finding significant antimicrobial resistance and virulence genes.

Local accessory gene sharing drives lineage-specific acquisition of antimicrobial resistance in Egyptian Campylobacter spp.

This study analyzes Campylobacter isolates from Egypt to show increased local accessory genome sharing in specific lineages, contributing to higher antimicrobial resistance in C. coli.

Host ecology regulates interspecies recombination in bacteria of the genus Campylobacter

The paper quantifies horizontal gene transfer (HGT) between Campylobacter species with different host ecologies, showing cohabitation in the same host increases HGT by 6-fold.

Non-serotype 2 isolates from healthy pigs are a potential zoonotic reservoir of Streptococcus suis genetic diversity and antimicrobial resistance

The paper identifies non-serotype 2 Streptococcus suis isolates from healthy pigs as a reservoir of genetic diversity and antimicrobial resistance, which may contribute to zoonotic transmission and treatment failure.

Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations

This study shows H. pylori has spread repeatedly from Africa by replacing strains with deleterious mutations through migration and selection.

A two-hit epistasis model prevents core genome disharmony in recombining bacteria

The paper shows that recombination in bacteria can overcome genomic disharmony through a two-hit epistasis model, allowing beneficial gene combinations to be reinstated in new genetic backgrounds.

Multiple clones of colistin-resistant Salmonella enterica carrying mcr-1 plasmids in meat products and patients in Northern Thailand

The paper identifies colistin-resistant Salmonella enterica clones carrying mcr-1 plasmids in meat and human cases in Northern Thailand, showing genetic relatedness between isolates.

Domestication of Campylobacter jejuni NCTC 11168

This study compares genetic and phenotypic variation in 23 isolates of the reference Campylobacter jejuni strain NCTC 11168, showing significant genomic and phenotypic differences despite being considered identical.

Hidden antibiotic resistance fitness costs revealed by GWAS-based epistasis analysis

The paper identifies hidden fitness costs of mupirocin resistance in Staphylococcus aureus using GWAS and proteomics, revealing pleiotropic effects on toxin production and virulence.