Author

A. Castillo Morales

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Biology Disciplines

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Evolutionary Biology· 1

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Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1 Organism:virus· 1 Assay:whole-genome sequencing· 1

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A. M. Rice· 1 shared A. T. Ho· 1 shared B. Young· 1 shared C. Mordstein· 1 shared G. Kudla· 1 shared L. Cano· 1 shared L. D. Hurst· 1 shared S. Mühlhausen· 1 shared

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2020-2020 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperEvolutionary Biology

A. M. Rice

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1 paper

Recent·Most cited

Evolutionary BiologybioRxivPreprintMay 11, 2020

Evidence for strong mutation bias towards, and selection against, T/U content in SARS-CoV2: implications for attenuated vaccine design.

A. M. Rice, A. Castillo Morales, A. T. Ho…·L. D. Hurst

The paper analyzes SARS-CoV-2 mutation patterns to show strong T/U mutation bias and selection against T, suggesting a strategy for vaccine attenuation by increasing usage of common synonymous codons.

DOI 10.1101/2020.05.11.088112

viruswhole-genome sequencing

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