BiophysicsbioRxiv
Activation mechanism of Small Heat Shock Protein HSPB5 revealed by disease-associated mutants.
C. N. Woods, M. K. Janowska, L. D. Ulmer…·R. E. Klevit
This study investigates the activation mechanism of HSPB5 by comparing wild-type and disease-associated mutants, revealing that mutations cause constitutive activation and increased co-aggregation propensity.
DOI 10.1073/pnas.2425061122