Cancer BiologybioRxiv
SETDB1 Fuels the Lung Cancer Phenotype by Modulating Epigenome, 3D Genome Organization and Chromatin Mechanical Properties
V. Zakharova, M. Magnitov, L. Del-Maestro…·S. Ait-Si-Ali
This study shows that SETDB1 loss-of-function in lung cancer cells alters chromatin structure, nuclear mechanics, and gene expression, reversing oncogenic properties.