Subnanometer-resolution structure determination in situ by a hybrid subtomogram averaging - single particle cryoEM - workflow
R. Sanchez, Y. Zhang, W. Chen, L. Dietrich, M. Kudryashev
The paper introduces a hybrid workflow combining subtomogram averaging and single-particle cryoEM to improve resolution in structural determination, achieving subnanometer resolution for tobacco mosaic virus and RyR1 ion channel.
bioRxiv · Apr 24, 2020Biochemistry