Author

L. Doetsch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

E. Hennes· 2 shared H. Waldmann· 2 shared P. Janning· 2 shared S. Sievers· 2 shared S. Ziegler· 2 shared A. Brause· 1 shared A. Kumar· 1 shared B. A. Schulmann· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

E. Hennes

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Monovalent Pseudo-Natural Product Degraders Supercharge the Native Degradation of IDO1 by KLHDC3

E. Hennes, B. Lucas, N. S. Scholes, X.-f. Cheng, D. C. Scott, M. Bischoff, K. Reich, R. Gasper, M. Lucas, T. T. Xu, L.-M. Pulvermacher, L. Doetsch, H. Imrichova, A. Brause, K. R. Naredla, , H. Waldmann

The paper identifies iDegs, which enhance IDO1 degradation via the native CRL2KLHDC3 pathway, reducing kynurenine formation and offering new therapeutic potential for cancer.

bioRxiv · Jul 10, 2024Cell Biology

Discovery of the sEH Inhibitor Epoxykynin as Potent Kynurenine Pathway Modulator

L. Doetsch, C. Davies, E. Hennes, J. Schoenfeld, A. Kumar, C. Da Cruz Lopes Guita, J. H. M. Ehrler, K. Hiesinger, S. Thavam, P. Janning, S. Sievers, S. Knapp, E. Proschak, S. Ziegler, H. Waldmann

The paper identifies epoxykynin as a potent sEH inhibitor that modulates the kynurenine pathway, offering new opportunities to address cancer-induced immune tolerance.

bioRxiv · Nov 9, 2023Cell Biology