Author

S. Sievers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Approach:deep learning· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

H. Waldmann· 5 shared S. Ziegler· 4 shared A. Pahl· 3 shared J. Warmers· 2 shared P. Janning· 2 shared S. Koska· 2 shared S. Rezaei Adariani· 2 shared A. Burhop· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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5 shared papersCell Biology

H. Waldmann

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Discovery of the sEH Inhibitor Epoxykynin as Potent Kynurenine Pathway Modulator

L. Doetsch, C. Davies, E. Hennes, J. Schoenfeld, A. Kumar, C. Da Cruz Lopes Guita, J. H. M. Ehrler, K. Hiesinger, S. Thavam, P. Janning, S. Sievers, S. Knapp, E. Proschak, S. Ziegler, H. Waldmann

The paper identifies epoxykynin as a potent sEH inhibitor that modulates the kynurenine pathway, offering new opportunities to address cancer-induced immune tolerance.

bioRxiv · Nov 9, 2023Cell Biology

Detection of a Mitochondrial Stress Phenotype using the Cell Painting Assay

S. Rezaei Adariani, D. Agne, S. Koska, A. Burhop, J. Warmers, P. Janning, M. Metz, A. Pahl, S. Sievers, H. Waldmann, S. Ziegler

The paper shows that the Cell Painting assay can detect mitochondrial stress and predict mitochondrial toxicity in small molecules.

bioRxiv · Nov 8, 2023 · PreprintCell Biology

Illuminating Dark Chemical Matter using the Cell Painting Assay

A. Pahl, J. Liu, S. Patil, S. Rezaei Adariani, B. Scholermann, J. Bonowski, S. Koska, S. Sievers, J. Warmers, S. Ziegler, H. Waldmann

The paper uses the Cell Painting Assay to identify bioactive compounds in dark chemical matter, revealing modulators of microtubules, DNA synthesis, and pyrimidine biosynthesis.

bioRxiv · May 31, 2023Cell Biology

Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP

M. Cigler, H. Imrichova, F. Frommelt, L. Depta, A. Rukavina, C. Kagiou, J. T. Hannich, C. Mayor-Ruiz, G. Superti-Furga, S. Sievers, L. Laraia, H. Waldmann, G. E. Winter

This study identifies orpinolide as a compound that disrupts cholesterol transport in leukemia by targeting OSBP, revealing a therapeutic strategy for leukemic dependencies.

bioRxiv · Mar 15, 2023 · PreprintPharmacology & Toxicology

Morphological Subprofile Analysis for Bioactivity Annotation of Small Molecules

A. Pahl, B. Schoelermann, M. Rusch, M. Dow, C. Hedberg, A. Nelson, S. Sievers, H. Waldmann, S. Ziegler

This paper introduces subprofile analysis to predict the mode of action of small molecules using morphological profiling data, enabling rapid bioactivity annotation without requiring extensive reference compounds.

bioRxiv · Aug 15, 2022Cell Biology

Work horse strain Clostridioides difficile 630Δerm is oblivious to its anaerobic lifestyle

D. Troitzsch, H. Zhang, S. Dittmann, D. Düsterhöft, A.-M. Michel, L. Jänsch, K. Riedel, J. M. Borrero-de Acuna, D. Jahn, S. Sievers

The study shows that the C. difficile strain 630Δerm has a mutation in PerR that causes oxidative stress response under anaerobic conditions, challenging its use as a model strain.

bioRxiv · Jan 7, 2020 · PreprintMicrobiology